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Merck

5.04842

CGP 37849

Synonym(s):

CGP 37849, (E)-(±)-2-Amino-4-methyl-5-phosphono­-3-pentenoic acid

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About This Item

Empirical Formula (Hill Notation):
C6H12NO5P
CAS Number:
127910-31-0
Molecular Weight:
209.14
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00153906

Key Documents

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SMILES string

[P](=O)(O)(O)C\C(=C\C(N)C(=O)O)\C

InChI

1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+

InChI key

BDYHNCZIGYIOGJ-DUXPYHPUSA-N

assay

≥99% (HPLC)

form

solid

potency

35 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

H2O: 100 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
NMDA receptors

Disclaimer

Toxicity: Standard Handling (A)

General description

A highly potent competitive antagonist selective for NMDA receptors (Ki = 35 nM). Biologically viable admitted orally or systematically. Widely used in studies of epilepsy, schizophrenia, depression, stress and anxiety related mental disorders.

Other Notes

Serafini, G., et al. 2013. Curr. Pharmaceut. Design19, 1898.
Szewczyk, B., et al. 2012. Expert. Op. Invest. Drugs21, 91.
Przegalinski, E., et al. 2000. Neuropharmacol.39, 1858.
Maj, J., et al. 1993. Polish J. Pharmacol.45, 455.
Fagg, E., et al. 1990. Br. J. Pharmacol.99, 791.
Schmutz, M., et al. 1990. Naunyn-Schmiedebergʹs Arch. Pharmacol.342, 61.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubilization.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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