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Merck

5.04844

7-Chlorokynurenic Acid Sodium Salt

Synonym(s):

7-Chlorokynurenic Acid Sodium Salt, 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H5ClNNaO3
CAS Number:
1263094-00-3
Molecular Weight:
245.59
MDL number:
MFCD12195840
UNSPSC Code:
12352106
NACRES:
NA.77

Key Documents

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SMILES string

[Na+].Clc1cc2[nH]c(c[c](c2cc1)=O)C(=O)[O-]

InChI

1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1

InChI key

IFZYIORLNGNLEI-UHFFFAOYSA-M

assay

≥99% (HPLC)

form

solid

potency

0.56 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 100 mM

Quality Level

100

General description

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.

Biochem/physiol Actions

Primary Target
NMDA receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A.85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol.280, 37.
Bartlett, D., et al. 1999. Neuropharmacol.37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol.199, 32.
Stone, W., et al. 2012. FEBS J.279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc.12, 64.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
5.04844.000104055977243611

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