5.04913
Aniracetam
Synonym(s):
Aniracetam, 1-(4-methoxybenzoyl)pyrrolidin-2-one, Draganon, Sarpul, Ampamet, Memodrin, Referan, Memodrin, Referan, 1-(4-methoxybenzoyl)pyrrolidin-2-one, Draganon, Sarpul, Ampamet
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About This Item
Empirical Formula (Hill Notation):
C12H13NO3
CAS Number:
Molecular Weight:
219.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
storage temp.
2-8°C
SMILES string
N2(CCCC2=O)C(=O)c1ccc(cc1)OC
InChI
1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
InChI key
ZXNRTKGTQJPIJK-UHFFFAOYSA-N
General description
A positive allosteric modulator selective for AMPA receptors. Slows down AMPA receptor deactivation rate without altering the agonist potency. A leading candidate of ampakine nootropic for cognitive enhancement. Widely used in studies in a variety of brain functions (i.e. learn and memory, cognition) and disorders (depression, anxiety disorder, Alzheimer′s disease, and aging).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
AMPA receptors
AMPA receptors
Other Notes
Koliaki, C., et al. 2012. CNS Neuroscience & Therapeutics.18, 302.
Lynch, G., et al. 2011. Pharmacol. Biochem. Behav.99, 116.
Nakamura, K., et al. 2001. Eur. J. Pharmacol.420, 33.
Ito, I. et al., 1990. J. Physiol.424, 553.
Isaacson et al., 1991. PNAS.88, 1093.
Lynch, G., et al. 2011. Pharmacol. Biochem. Behav.99, 116.
Nakamura, K., et al. 2001. Eur. J. Pharmacol.420, 33.
Ito, I. et al., 1990. J. Physiol.424, 553.
Isaacson et al., 1991. PNAS.88, 1093.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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