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Merck

5.04914

CNQX

Synonym(s):

CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline

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About This Item

Empirical Formula (Hill Notation):
C9H4N4O4
CAS Number:
115066-14-3
Molecular Weight:
232.15
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00069232
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

[N+](=O)([O-])c1cc2[nH][c]([c]([nH]c2cc1C#N)=O)=O

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white to yellow

solubility

DMSO: 25 mg/mL

storage temp.

2-8°C

Quality Level

100

General description

A potent and competitive antagonist for AMPA/kainate receptors (Ki = 0.6 - 2.11 µM for GluA1-4 and Ki = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Secondary Target
Kainate
Target Ki: 0.6 – 2.11 →M for GluA1 – 4 and Ki

Other Notes

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
King, A., et al. 1992. Br. J. Pharmacol.107, 375.
Long, S. et al. 1990. Br. J. Pharmacol.100, 850.Harris, K., et al. 1989. Brain Res.5, 185Honore, T., et al. 1988. Science.241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol.156, 177.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
5.04914.000104055977263688

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