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Key Documents

5.04983

Sigma-Aldrich

S18986

Synonym(s):

S18986, (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, AMPA Receptor Positive Allosteric Modulator, S18986

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O2S
CAS Number:
175340-20-2
Molecular Weight:
224.28
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

2-8°C

InChI

1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1

InChI key

MNTIJYGEITVWHU-SNVBAGLBSA-N

General description

A positive allosteric modulator selective for the AMPA receptors. A nootropic and neuroprotective agents frequently used in researches studying cognition, memory, and aging related cognitive declines. Induces production of BNDF and AMPA-mediated release of noradrenaline and acetylcholine. Biologically viable admitted systematically.

Biochem/physiol Actions

Primary Target
AMPA
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gupta, K., et al. 2009. Cell Death & Differentiation.16, 624.

Marighetto, A., et al. 2008. Beh. Pharmacol.19, 235.
Bloss, B., et al. 2008. Exp. Neurol.210, 109.
Lockhart, P., et al. 2007. Eur. J. Pharmacol.561, 23.
Munoz, C., et al. 2004. Neurobiol. Aging.25, S224.
Rosi, S., et al. 2004. Neurosci. Lett.361, 120.
Lebrun, C., et al. 2000. Eur. J. Pharmacol.401, 205.
Lockhart, B., et al. 2000. Eur. J. Pharmacol.401, 145.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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