UBP310

Name: UBP310
Brand: MM

Synonym(s):

UBP310, GluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione, UBP-310, UBP 310

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₅N₃O₆S

CAS Number:

902464-46-4

Molecular Weight:

353.35

UNSPSC Code:

12352200

Assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

10 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

2-8°C

InChI

1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1

InChI key

ZTAZUCRXCRXNSU-VIFPVBQESA-N

General description

A potent antagonist highly selective for GluK1 (K_b = 10 nM), GluK3 (IC₅₀ = 23 nM), and GluK1/K5 (K_b = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (K_d = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.

Biochem/physiol Actions

Primary Target
GluK1

Secondary Target
Gluk3

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pinheiro, S., et al. 2013. Cereb. Cort.23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol.78, 1036.
Perrais, D., et al. 2009. Neuropharmacol.56, 131.
Dolman, P., et al. 2007. J. Med. Chem.50, 1558.
Mayer, L., et al. 2006. J. Neurosci.26, 2852.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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