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5.05145

(+)-Tubocurarine Chloride

Synonym(s):

(+)-Tubocurarine Chloride, Nicotinic Acetylcholine Receptor Antagonist, (+)-Tubocurarine chloride, D-tubocurarine, DTC

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About This Item

Empirical Formula (Hill Notation):
C37H42Cl2N2O6
CAS Number:
57-94-3
Molecular Weight:
681.65
MDL number:
MFCD00013471
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

H2O: soluble

storage temp.

−20°C

SMILES string

[Cl-].[Cl-].[N+]1([C@@H]2Cc3cc(c(cc3)O)Oc4cc5c(cc4OC)CC[N+H]([C@H]5Cc6ccc(cc6)Oc7c2c(cc(c7O)OC)CC1)C)(C)C

InChI

1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1

InChI key

GXFZCDMWGMFGFL-KKXMJGKMSA-N

General description

A potent competitive antagonist of nAChR (IC50= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

Biochem/physiol Actions

Primary Target
nAch

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warming is required for complete solubilization.

Other Notes

Bowman, C., 2006. Br. J. Pharmacol.147, S277.
Wenningmann, I., et al. 2001. Mol. Pharmacol.60, 790.
Pederson, X., 1990. Proc. Natl. Acad. Sci. USA.87, 2785.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

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