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Merck

5.05207

Mecamylamine Hydrochloride

Synonym(s):

Mecamylamine Hydrochloride, N,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H21N · xHCl
CAS Number:
826-39-1
Molecular Weight:
167.29 (free base basis)
UNSPSC Code:
12352116
NACRES:
NA.77
MDL number:
MFCD00151462
Assay:
≥98% (TLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

[Cl-].N(C1(C2CC(C1(C)C)CC2)C)C.[H+]

InChI

1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H

InChI key

PKVZBNCYEICAQP-UHFFFAOYSA-N

assay

≥98% (TLC)

form

solid

potency

640 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

H2O: 100 mM

storage temp.

2-8°C

Quality Level

100

General description

A potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette′s syndrome, Schizophrenia and various cognitive and mood disorders).

Biochem/physiol Actions

Primary Target
nAChR
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Harris, C., et al. 2013. Psychopharmacol.225, 291.
Lima, H., et al. 2013. Learning & Memory20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
5.05207.000104055977263435

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