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Merck

5.05222

RuBi-Nicotine

Synonym(s):

RuBi-Nicotine, Bis(2,2′-bipyridine-N,N′)bis(S-nicotine-N1) ruthenium(2+) dichloride complex Bis(2,2ʹ-bipyridine-N,Nʹ)bis(S-nicotine-N1) ruthenium(2+) dichloride complex , Nicotinic Cholinergic Receptor Agonist, RuBi-Nicotine, nAChR Receptor Agonist, RuBi-Nico

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About This Item

Empirical Formula (Hill Notation):
C40H44Cl2N8Ru
CAS Number:
Molecular Weight:
808.81
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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SMILES string

[Ru+2]85([NH]9=CC=CC=C9C%10=CC=CC=[NH]%108)([NH]6=CC=CC=C6C7=CC=CC=[NH]75)([NH]3=CC=CC(=C3)[C@H]4N(CCC4)C)[NH]1=CC=CC(=C1)[C@H]2N(CCC2)C.[Cl-].[Cl-]

InChI

1S/2C10H14N2.2C10H8N2.2ClH.Ru/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*1-3-7-11-9(5-1)10-6-2-4-8-12-10;;;/h2*2,4,6,8,10H,3,5,7H2,1H3;2*1-8H;2*1H;/q;;;;;;+2/p-2/t2*10-;;;;;/m00...../s1

InChI key

BQXVYFYPLMVART-ZPFSJBFKSA-L

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

deep orange

storage temp.

−20°C

Quality Level

solubility

methanol: 100 mM

Biochem/physiol Actions

Primary Target
nAChR

Disclaimer

Toxicity: Toxic (F)

General description

A highly water soluble Ruthenium-bisbipyridine-caged nicotine that can be un-caged by blue and green light. Rapid nicotine release (<20 ns) and fast biological effects in vivo.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Filevich, O., et al. 2010. J. Inorg. Biochem.104, 51.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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