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5.05226

Pancuronium Dibromide

Synonym(s):

Pancuronium Dibromide, 1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide

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About This Item

Empirical Formula (Hill Notation):
C35H60N2O4 · Br2
CAS Number:
15500-66-0
Molecular Weight:
732.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00079223
Assay:
≥98% (NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
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assay

≥98% (NMR)

Quality Segment

100

form

solid

potency

5.5 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

water: 100 mM

storage temp.

2-8°C

SMILES string

[Br-].[Br-].[N+]6(CCCCC6)([C@@H]1[C@@H]([C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@@H]([C@H](C4)[N+]5(CCCCC5)C)OC(=O)C)CC3)C)CC2)C1)C)OC(=O)C)C

InChI

1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key

NPIJXCQZLFKBMV-YTGGZNJNSA-L

General description

A highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.

Biochem/physiol Actions

Primary Target
nAChR

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lowenick et al., 2001. Eur. J. Pharmacol.413, 31.

Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.

Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.

Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

5052260002: + 5052260001:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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