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5.05226

Pancuronium Dibromide

Name: Pancuronium Dibromide
Brand: MM

Synonym(s):

Pancuronium Dibromide, 1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide

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About This Item

Empirical Formula (Hill Notation):

C₃₅H₆₀N₂O₄ · Br₂

CAS Number:

15500-66-0

Molecular Weight:

732.67

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00079223

Assay:

≥98% (NMR)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (NMR)

Quality Segment

100

form

solid

potency

5.5 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

water: 100 mM

storage temp.

2-8°C

SMILES string

[Br-].[Br-].[N+]6(CCCCC6)([C@@H]1[C@@H]([C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@@H]([C@H](C4)[N+]5(CCCCC5)C)OC(=O)C)CC3)C)CC2)C1)C)OC(=O)C)C

InChI

1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key

NPIJXCQZLFKBMV-YTGGZNJNSA-L

Description

General description

A highly potent competitive antagonist selective for nAChRs (IC₅₀ = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.

Biochem/physiol Actions

Primary Target
nAChR

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lowenick et al., 2001. Eur. J. Pharmacol.413, 31.

Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.

Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.

Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H301

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)