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Merck

5.05228

Sigma-Aldrich

S 24795

Synonym(s):

S 24795, alpha 7 Nicotinic Acetylcholine Receptor Agonist, S 24795, 2-(2-(4-bromophenyl)-2-oxoethyl)-1-methylpyridin-1-ium iodide, alpha 7 nAChR agonist, S 24795, S-24795, S24795

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About This Item

Empirical Formula (Hill Notation):
C14H13BrINO
CAS Number:
304679-75-2
Molecular Weight:
418.07
MDL number:
MFCD18086873
UNSPSC Code:
12352200

Assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pink

solubility

DMSO: 100 mM

storage temp.

−20°C

InChI

1S/C14H13BrNO.HI/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11;/h2-9H,10H2,1H3;1H/q+1;/p-1

InChI key

LERUHBBUGAOYOD-UHFFFAOYSA-M

General description

A potent partial agonist selective for α7 nAChRs (EC50 = 34 µM). Widely used in investigating the roles of α7 nAChRs in aging, learning and memory, and cognition. Enhances memory in mouse models for Alzheimer′s disease.

Biochem/physiol Actions

Primary Target
→7 nAChRs

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tronche, C., et al., 2010. Behav Brain Res.215, 255.

Beracochea, D., et al., 2008. Psychopharmacol. (Berl).196, 555.
Lagostena, L., et al., 2008. Neuropharmacol.54, 676.

Lopez-Hernandez, G., et al., 2007. Neuropharmacol.53, 134.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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