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5.05228

S 24795

Synonym(s):

S 24795, alpha 7 Nicotinic Acetylcholine Receptor Agonist, S 24795, 2-(2-(4-bromophenyl)-2-oxoethyl)-1-methylpyridin-1-ium iodide, alpha 7 nAChR agonist, S 24795, S-24795, S24795

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About This Item

Empirical Formula (Hill Notation):
C14H13BrINO
CAS Number:
304679-75-2
Molecular Weight:
418.07
UNSPSC Code:
12352200
MDL number:
MFCD18086873
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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assay

≥99% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pink

solubility

DMSO: 100 mM

storage temp.

−20°C

InChI

1S/C14H13BrNO.HI/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11;/h2-9H,10H2,1H3;1H/q+1;/p-1

InChI key

LERUHBBUGAOYOD-UHFFFAOYSA-M

General description

A potent partial agonist selective for α7 nAChRs (EC50 = 34 µM). Widely used in investigating the roles of α7 nAChRs in aging, learning and memory, and cognition. Enhances memory in mouse models for Alzheimer′s disease.

Biochem/physiol Actions

Primary Target
→7 nAChRs

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tronche, C., et al., 2010. Behav Brain Res.215, 255.

Beracochea, D., et al., 2008. Psychopharmacol. (Berl).196, 555.
Lagostena, L., et al., 2008. Neuropharmacol.54, 676.

Lopez-Hernandez, G., et al., 2007. Neuropharmacol.53, 134.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

5052280002: + 5052280001:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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