Key Documents

View All Documentation

5.05275

ICI 118551 Hydrochloride

Name: ICI 118551 Hydrochloride
Brand: MM

≥98% (HPLC), selective β2 adrenergic inverse agonist, solid

Synonym(s):

ICI 118551 Hydrochloride, (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₇NO₂ · xHCl

CAS Number:

72795-19-8

Molecular Weight:

277.40 (free base basis)

MDL number:

MFCD01074480

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

ICI 118551 Hydrochloride,

assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mg/mL

storage temp.

10-30°C

SMILES string

N([C@H]([C@@H](O)COc1c2c(c(cc1)C)CCC2)C)C(C)C

InChI

1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/m0/s1

InChI key

VFIDUCMKNJIJTO-BBRMVZONSA-N

Description

General description

ICI-118,551 reduces hemangioblastoma viability by promoting cell apoptosis and inhibits the formation of hemangiospheres from VHL tumor cells. This antiangiogenic agent inhibits HIF-target genes. It also blocks constitutively activated HIF signaling in hemangioblastomas associated with von Hippel-Lindau disease. ICI-118,551 is a potent inhibitor of isoprenaline-stimulated adenylate cyclase activity in rabbit ciliary process cell preparations.

Biochem/physiol Actions

Primary Target
→2 adrenergic receptors

Reversible: yes

Target K_i: 1.2, 120 and 257 nM for →2, →1 and →3 receptors respectively.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bilski, A., et al. 1983. J. Cardiovasc. Pharmacol.5, 430.
Cook, S. et al. 1993. Br. J .Pharmacol.109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol.275, 199.
Strosberg, A., et al. 1996. TiPS17, 373.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The beta2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease

Cuesta AM, et al.

Scientific Reports, 9(1), 10062-10062 (2019)