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5.05277

GTS-21 Dihydrochloride (DMBX-A)

Synonym(s):

GTS-21 Dihydrochloride (DMBX-A), E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21

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About This Item

Empirical Formula (Hill Notation):
C19H20N2O2 · 2HCl
CAS Number:
156223-05-1
Molecular Weight:
381.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00941364
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mM, H2O: 100 mM

storage temp.

−20°C

SMILES string

[Cl-].[Cl-].n1cc(ccc1)C2=NCCC\C\2=C/c3c(cc(cc3)OC)OC.[H+].[H+]

InChI

1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;

InChI key

BXKYFUGAAFLYJL-BXGYHSFXSA-N

General description

A partial agonist selective for α7 nAChRs (EC50 = 10 µM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer′s disease studies.

Biochem/physiol Actions

Primary Target
α7 nAChR
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kox, M., et al. 2011. Br. J. Anaesth.107, 559.
Kox, M., et al., 2011. Shock.36, 5.
Rosas-Ballina, M., et al. 2009. Mol. Med.15, 195.
Briggs, A., et al. 1997. Pharmacol. Biochem. Behav.57, 231.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

5052770001: + 5052770002:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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