5.05315
A 438079
Synonym(s):
A 438079, 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
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About This Item
Empirical Formula (Hill Notation):
C13H9Cl2N5 · xHCl
CAS Number:
Molecular Weight:
306.15 (free base basis)
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mM
storage temp.
2-8°C
InChI
1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H
InChI key
MBTJFFMIPPMRGR-UHFFFAOYSA-N
General description
A potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5 nM and 6.9 nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300 nM at rat and human P2X7 receptors, respectively.
Biochem/physiol Actions
Primary Target
P2X₇
P2X₇
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Donnelly-Roberts, et al., 2007, Br. J. Pharmacol.101, 571.
Wang B, et al., 2013, Purinergic Signal.9, 101.
Wang B, et al., 2013, Purinergic Signal.9, 101.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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