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Merck

5.05316

PHA-543,613

Synonym(s):

PHA-543,613, N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613

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About This Item

Empirical Formula (Hill Notation):
C15H17N3O2
CAS Number:
478149-53-0
Molecular Weight:
271.31
UNSPSC Code:
12352200

Key Documents

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InChI key

IPKZCLGGYKRDES-ZDUSSCGKSA-N

InChI

1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 20 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
α7 nAChR

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent agonist highly selective for α7 nicotinic acetylcholine receptor (α7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of α7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer′s disease.

Other Notes

Mazurov, A., et al., 2011. J. Med. Chem.54, 7943.
Wishka, G., et al., 2006. J. Med. Chem.49, 4425.
Faghih, R., et al., 2008. J. Med. Chem.51, 701.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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