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5.05413

5-Iodo-A-85380 dihydrochloride hydrate

Name: 5-Iodo-A-85380 dihydrochloride hydrate
Brand: MM

Synonym(s):

5-Iodo-A-85380 dihydrochloride hydrate, 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₁IN₂O · 2HCl · xH₂O

CAS Number:

213550-82-4

Molecular Weight:

363.02 (anhydrous basis)

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

water: 22 mg/mL

storage temp.

2-8°C

InChI

1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1

InChI key

RKVRGRXOYDTUEY-QMMMGPOBSA-N

Description

General description

A very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (K_i= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.

Biochem/physiol Actions

Primary Target
α4β2 nAChR

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Liu, X., et al., 2013. Psychopharm.In press.

Kennett, A., et al., 2012. Nicotine Tob. Res.14, 1339.

Huang. LZ, et al., 2011. Neuropharm.60, 861.
Mogg. AJ, et al., 2004. Neuropharm.60, 861.

Mukhin, A.G., et al., 2000. Mol. Pharmacol.47, 848.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c