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Merck

5.05413

5-Iodo-A-85380 dihydrochloride hydrate

Synonym(s):

5-Iodo-A-85380 dihydrochloride hydrate, 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380

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About This Item

Empirical Formula (Hill Notation):
C9H11IN2O · 2HCl · xH2O
CAS Number:
213550-82-4
Molecular Weight:
363.02 (anhydrous basis)
UNSPSC Code:
12352200

Key Documents

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InChI key

RKVRGRXOYDTUEY-QMMMGPOBSA-N

InChI

1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: 22 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
α4β2 nAChR

Disclaimer

Toxicity: Standard Handling (A)

General description

A very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (Ki= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.

Other Notes

Liu, X., et al., 2013. Psychopharm.In press.

Kennett, A., et al., 2012. Nicotine Tob. Res.14, 1339.

Huang. LZ, et al., 2011. Neuropharm.60, 861.
Mogg. AJ, et al., 2004. Neuropharm.60, 861.

Mukhin, A.G., et al., 2000. Mol. Pharmacol.47, 848.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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