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5.05483

Sigma-Aldrich

FFN511

Synonym(s):

FFN511, Fluorescent False Neurotransmitter 511, Vesicle Monoamine Transporter (VMAT2) Substrate, FFN511

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About This Item

Empirical Formula (Hill Notation):
C17H20N2O2
CAS Number:
1004548-96-2
Molecular Weight:
284.35
UNSPSC Code:
12352200

Assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

1 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 5 mM

storage temp.

−20°C

InChI

1S/C17H20N2O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17/h9-10H,1-8,18H2

InChI key

SKTIZSRPCXRDHX-UHFFFAOYSA-N

General description

A fluorescent false neurotransmitter that acts as an optical tracer that inhibits serotonin binding to VMAT2-containing membranes (IC50 = 1 µM). Compound has been used to assess the functional status of TH positive neurons by fluorescent measurement of uptatke and release.

Biochem/physiol Actions

Primary Target
VMAT2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Dulcis, D. et al. 2013. Science340, 449.
Gubernator, N. G. et al. 2009. Science324, 1441.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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