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Merck

5.05483

FFN511

Synonym(s):

FFN511, Fluorescent False Neurotransmitter 511, Vesicle Monoamine Transporter (VMAT2) Substrate, FFN511

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About This Item

Empirical Formula (Hill Notation):
C17H20N2O2
CAS Number:
1004548-96-2
Molecular Weight:
284.35
UNSPSC Code:
12352200

Key Documents

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InChI key

SKTIZSRPCXRDHX-UHFFFAOYSA-N

InChI

1S/C17H20N2O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17/h9-10H,1-8,18H2

assay

≥99% (HPLC)

form

solid

potency

1 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 5 mM

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Primary Target
VMAT2

Disclaimer

Toxicity: Standard Handling (A)

General description

A fluorescent false neurotransmitter that acts as an optical tracer that inhibits serotonin binding to VMAT2-containing membranes (IC50 = 1 µM). Compound has been used to assess the functional status of TH positive neurons by fluorescent measurement of uptatke and release.

Other Notes

Dulcis, D. et al. 2013. Science340, 449.
Gubernator, N. G. et al. 2009. Science324, 1441.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Niko G Gubernator et al.
Science (New York, N.Y.), 324(5933), 1441-1444 (2009-05-09)
The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. In order to observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter.
Davide Dulcis et al.
Science (New York, N.Y.), 340(6131), 449-453 (2013-04-27)
Neurotransmitters have been thought to be fixed throughout life, but whether sensory stimuli alter behaviorally relevant transmitter expression in the mature brain is unknown. We found that populations of interneurons in the adult rat hypothalamus switched between dopamine and somatostatin

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