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5.05626

(S)-Sulpiride

Name: (S)-Sulpiride
Brand: MM

Synonym(s):

(S)-Sulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, D2-like dopamine antagonist, (s)-Sulpiride, Sulpiride

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₃N₃O₄S

CAS Number:

23672-07-3

Molecular Weight:

341.43

UNSPSC Code:

12352200

MDL number:

MFCD00055220

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥99% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

2-8°C

InChI

1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

InChI key

BGRJTUBHPOOWDU-UHFFFAOYSA-N

Description

General description

Dopamine D2 receptor antagonist with good aqueous solubility. S-sulpiride (200 nm) was used to confirm that dopamine currents were mediated through the D2 receptor in whole animal rat brain preps. IC₅₀ of 0.01012 µM Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis.

Biochem/physiol Actions

Primary Target
D2-like dopamine receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Eagle, D. M. et al. 2011. J. Neurosci.31, 7349.
Banala, A. K. et al. 2011. J. Med. Chem.54, 3581.
Seeman, P. and Van Tol, H. H. 1994. Trends Pharmacol. Sci.15, 264.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

5056260001: + 5056260002:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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