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Merck

5.05723

SCH 23390 Hydrochloride

Synonym(s):

SCH 23390 Hydrochloride, Dopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390

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About This Item

Empirical Formula (Hill Notation):
C17H18ClNO · xHCl
CAS Number:
125941-87-9
Molecular Weight:
287.78 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00069249

Key Documents

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InChI

1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChI key

OYCAEWMSOPMASE-XFULWGLBSA-N

assay

≥99% (HPLC)

form

solid

potency

0.2 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: 100 mM

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Primary Target
D1 and D5

Disclaimer

Toxicity: Standard Handling (A)

General description

A highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).

Other Notes

Splinter, M. Y. 2007. Ann. Pharmacother.41, 285.
Pfeiffer, R. F. 2002. Drugs Aging.19, 561.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Maria C Tickerhoof et al.
Psychoneuroendocrinology, 113, 104542-104542 (2019-12-22)
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