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5.05723

SCH 23390 Hydrochloride

Name: SCH 23390 Hydrochloride
Brand: MM

Synonym(s):

SCH 23390 Hydrochloride, Dopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈ClNO · xHCl

CAS Number:

125941-87-9

Molecular Weight:

287.78 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD00069249

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥99% (HPLC)

Quality Segment

100

form

solid

potency

0.2 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

water: 100 mM

storage temp.

−20°C

InChI

1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChI key

OYCAEWMSOPMASE-XFULWGLBSA-N

Description

General description

A highly potent and selective dopamine D1-like receptor antagonist with a K_i of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (K_i values are 6.3 nM and 9.3 nM respectively).

Biochem/physiol Actions

Primary Target
D1 and D5

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Splinter, M. Y. 2007. Ann. Pharmacother.41, 285.
Pfeiffer, R. F. 2002. Drugs Aging.19, 561.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c