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Key Documents

COA/COQ

5.05734

BzATP Triethylammonium Salt

Name: BzATP Triethylammonium Salt
Brand: MM

Synonym(s):

BzATP Triethylammonium Salt, 2ʹ(3ʹ)-O-(4-Benzoylbenzoyl)adenosine-5ʹ-triphosphate tri(triethylammonium) salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₄N₅O₁₅P₃ · 3C₆H₁₅N

CAS Number:

112898-15-4

Molecular Weight:

1018.96

MDL number:

MFCD00058547

UNSPSC Code:

12352200

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mM

storage temp.

−20°C

InChI

1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35);4-6H2,1-3H3/t16-,19-,20-,23-;/m1./s1

InChI key

HVOVBTNCGADRTH-WBLDMZOZSA-N

General description

A prototypic P2X₇ purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC₅₀ = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X₇-/- mice.

Other Notes

Messemer, N., et al. 2013. Neuropharmacology. 73, 122.
Michel, A.D., et al. 2001. Br. J. Pharmacol.132, 1501.
Erb, L., et al. 1990. J. Biol. Chem.265, 7424.

William, N., and Coleman, P.S. 1982. J. Biol. Chem.257, 2834.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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