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Merck

5.05757

Divin - Calbiochem

Synonym(s):

Divin - Calbiochem, Nʹ-(( E)-(2-Hydroxynaphthalen-1-yl)methylidene)-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide, ( E)-Nʹ-((2-Hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide, DIVision Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C22H20N4O2
Molecular Weight:
372.42
UNSPSC Code:
12352200

Key Documents

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assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Cell permeable: yes
Primary Target
bacteria

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, stable benzimidazolylpropanehydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability. Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5 µM against V. cholerae, C. crescentus CB15N strain and JW5503 and YJE24 strains of E. coli, respectively). Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells. Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes. Exhibits low toxicity in mammalian cells.

Other Notes

Eun, Y.J., et al. 2013. J. Am. Chem. Soc.135, 9768.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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