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About This Item
Empirical Formula (Hill Notation):
C16H16ClNO2S · xH2SO4
CAS Number:
Molecular Weight:
321.82 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 25 mg/mL
storage temp.
2-8°C
SMILES string
[S](=O)(=O)([O-])O.[s]1c2c(cc1)C[N+H](CC2)C(c3c(cccc3)Cl)C(=O)OC
InChI
1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)
InChI key
FDEODCTUSIWGLK-UHFFFAOYSA-N
General description
A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.
Biochem/physiol Actions
Primary Target
P2Y₁₂
P2Y₁₂
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Liu, O., et al. 2012. PLoS One.7, e51707.
Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.
Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Danger
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Storage Class
8A - Combustible corrosive hazardous materials
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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