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Merck

5.05771

4-DAMP

Synonym(s):

4-DAMP, 1,1-Dimethyl-4-diphenylacetoxypiper­idinium iodide, Muscarinic Receptor Antagonist, 4-DAMP

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About This Item

Empirical Formula (Hill Notation):
C21H26INO2
CAS Number:
1952-15-4
Molecular Weight:
451.34
UNSPSC Code:
12352200
MDL number:
MFCD00078564

Key Documents

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InChI

1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1

InChI key

WWJHRSCUAQPFQO-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

DMSO: 100 mM
ethanol: 25 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
Muscarinic Receptors
Target Ki: 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively

Disclaimer

Toxicity: Standard Handling (A)

General description

An antagonist selective for mAChRs (Ki = 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively). Used frequently in investigating the functional roles of M1 and M3 receptors in both central and peripheral nervous systems.

Other Notes

Kruse, C., et al., 2012. Nature.482, 552.
Moriya, H., et al., 1999. Life Sci.64, 2351.
Ehlert, J., 1996. Life Sci.58, 1971.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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