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5.05821

AF-DX 116

Name: AF-DX 116
Brand: MM

Synonym(s):

AF-DX 116, Muscarinic Receptor (mAChR) M2 antagonist, AF-DX 116, Otenzepad, AF-DX116, AF-DX-116, AFDX116

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₁N₅O₂

CAS Number:

102394-31-0

Molecular Weight:

421.54

MDL number:

MFCD00864743

UNSPSC Code:

12352200

Assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: soluble

storage temp.

2-8°C

InChI

1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)

InChI key

UBRKDAVQCKZSPO-UHFFFAOYSA-N

General description

Selective presynaptic muscarinic receptor M₂ antagonist with cardioselectivity. Exhibits antiarrhythmic effects in vivo, also shown to reverse the memory impairment effect of insulin in a mouse model.

Biochem/physiol Actions

Primary Target
M₂

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lanzafame A., et al. 2001. Eur J Pharmacol.416, 235.

Kopf S., et al. 1998. Neurobiol Learn Mem.70, 305.
Naito, H., et al. 1997. Heart Vessels.12, 229.
Hammer, R., et al. 1986. Life Sci.38, 1653.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)