5.05823
Galectin-1 Antagonist, DB21
Synonym(s):
Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
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About This Item
Empirical Formula (Hill Notation):
C83H132N18O17
Molecular Weight:
1654.05
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
potency
3 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 10 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Primary Target
Galectin-1
Galectin-1
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.
Other Notes
Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.
SVQMKNva-[DBF]-IIVKLNA
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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