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Merck

5.05878

PD 168077 Maleate

Synonym(s):

PD 168077 Maleate, D4 Dopamine Receptor Agonist, PD 168077 Maleate, PD168077, PD-168077

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About This Item

Empirical Formula (Hill Notation):
C20H22N4O · xC4H4O4
CAS Number:
630117-19-0
Molecular Weight:
334.41 (free base basis)
MDL number:
MFCD01321067
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

N2(CCN(CC2)c3c(cccc3)C#N)CNC(=O)c1cc(ccc1)C.OC(=O)\C=C/C(=O)O

InChI

1S/C20H22N4O.C4H4O4/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21;5-3(6)1-2-4(7)8/h2-8,13H,9-12,15H2,1H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

NAEUGRPISCANHO-BTJKTKAUSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
D₄
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A selective D4 dopamine receptor agonist (Ki = 8.7 nM, EC50 = 8.3 nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D2 and D3 Receptors (Ki = 2.8 µM).

Other Notes

Melis, M. R. et al. 2005. Neurosci. Lett.379, 59.
Bernaerts, P. et al. 2003. Behav. Brain Res.142, 41.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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