5.05879
L-741,626
Synonym(s):
L-741,626, Dopamine D2 Receptor Antagonist, L-741,626, L-741626, L741626
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About This Item
Empirical Formula (Hill Notation):
C20H21ClN2O
CAS Number:
Molecular Weight:
340.85
UNSPSC Code:
12352200
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
potency
7.1 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: soluble
storage temp.
2-8°C
InChI
1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
InChI key
LLBLNMUONVVVPG-UHFFFAOYSA-N
General description
Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
Biochem/physiol Actions
Primary Target
D₂
D₂
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett.17, 745.
Caine, S. B. et al. 2002. J. Neurosci.22, 2977.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Caine, S. B. et al. 2002. J. Neurosci.22, 2977.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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