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Merck

5.05897

(±)-PD 128907 Hydrochloride - CAS 112960-16-4 - Calbiochem

Synonym(s):

(±)-PD 128907 Hydrochloride - CAS 112960-16-4 - Calbiochem

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About This Item

Empirical Formula (Hill Notation):
C14H19NO3 · xHCl
CAS Number:
112960-16-4
Molecular Weight:
249.31 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00210210

Key Documents

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assay

≥98% (HPLC)

form

powder

potency

2.3 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 5 mg/mL

storage temp.

−20°C

Biochem/physiol Actions

Primary Target
D₃

Disclaimer

Toxicity: Standard Handling (A)

General description

Selective dopamine D3 receptor agonist (Ki = 2.3 nM) with an 18-fold selectivity over long dopamine receptors (D2L) and exhibited only weak affinity for D4.2 receptors (Ki = 169 nM). Commonly used to reproduce cocaine′s discriminative stimulus effects and also in peripheral systemic studies of hypertension.

Other Notes

Achat-Mendes, c. et al. 2010. J. Pharmacol. Exp. Ther.334, 556.

Zeng, C. et al. 2006. Circul. Res.99, 494.

Pugsley, T. A. et al. 1995. J. Pharmacol. Exp. Ther.275, 1355.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Chunyu Zeng et al.
Circulation research, 99(5), 494-500 (2006-08-12)
The dopaminergic and renin angiotensin systems interact to regulate blood pressure. Disruption of the D(3) dopamine receptor gene in mice produces renin-dependent hypertension. In rats, D(2)-like receptors reduce angiotensin II binding sites in renal proximal tubules (RPTs). Because the major
T A Pugsley et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1355-1366 (1995-12-01)
The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a dopamine (DA) receptor agonist that shows a preference for the human D3 receptor. In transfected Chinese hamster ovary cells (CHO K1), PD 128907 displaced [3H]spiperone
Cindy Achat-Mendes et al.
The Journal of pharmacology and experimental therapeutics, 334(2), 556-565 (2010-05-25)
Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized. This study investigated the role of D3 and D2 subtype mechanisms by determining

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