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5.05982

Sigma-Aldrich

(-)-Quinpirole Hydrochloride

Synonym(s):

(-)-Quinpirole Hydrochloride, Dopamine D₂ Receptor Agonist, Quinpirole, Quinpirole, LY-171,555, LY 171555

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About This Item

Empirical Formula (Hill Notation):
C13H21N3 · xHCl
CAS Number:
85798-08-9
Molecular Weight:
219.33 (free base basis)
MDL number:
MFCD00069336
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

Quality Level

100

form

powder

potency

4.8 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 7.3 mg/mL

storage temp.

−20°C

InChI

1S/C13H21N3.ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;/h9-10,13H,2-8H2,1H3,(H,14,15);1H/t10-,13-;/m1./s1

InChI key

HJHVRVJTYPKTHX-HTMVYDOJSA-N

General description

A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8 nM. Some D3(Ki = 24 nM) and D4 (Ki = 30 nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5 nM).

Other Notes

OʹNeill, C. et al. 2009. J. Neurochem.108, 545.
Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790.
Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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