5.05983
NS1738
別名:
NS1738, 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
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この商品について
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
InChI
1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
InChI key
OUDXRNQPVSMGDW-UHFFFAOYSA-N
General description
A biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
Biochem/physiol Actions
Primary Target
α7 AChR
α7 AChR
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther.344, 264.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。