5.05983
NS1738
Synonym(s):
NS1738, 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
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About This Item
Empirical Formula (Hill Notation):
C14H9Cl2F3N2O2
CAS Number:
Molecular Weight:
365.13
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
InChI
1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
InChI key
OUDXRNQPVSMGDW-UHFFFAOYSA-N
General description
A biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
Biochem/physiol Actions
Primary Target
α7 AChR
α7 AChR
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther.344, 264.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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