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Key Documents

COA/COQ

5.05983

NS1738

Name: NS1738
Brand: MM

Synonym(s):

NS1738, 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₉Cl₂F₃N₂O₂

CAS Number:

501684-93-1

Molecular Weight:

365.13

UNSPSC Code:

12352200

Assay

≥99% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

beige

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

InChI

1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)

InChI key

OUDXRNQPVSMGDW-UHFFFAOYSA-N

General description

A biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.

Biochem/physiol Actions

Primary Target
α7 AChR

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther.344, 264.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)