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Merck

5.05983

NS1738

Synonym(s):

NS1738, 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738

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About This Item

Empirical Formula (Hill Notation):
C14H9Cl2F3N2O2
CAS Number:
501684-93-1
Molecular Weight:
365.13
UNSPSC Code:
12352200

InChI key

OUDXRNQPVSMGDW-UHFFFAOYSA-N

InChI

1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)

assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

beige

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
α7 AChR

Disclaimer

Toxicity: Standard Handling (A)

General description

A biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.

Other Notes

Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther.344, 264.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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