Mitochondrial Content Inducer, BRD6897

Name: Mitochondrial Content Inducer, BRD6897
Brand: MM

Synonym(s):

Mitochondrial Content Inducer, BRD6897, BRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₁N₃O₂S₂

CAS Number:

618395-82-7

Molecular Weight:

459.58

MDL number:

MFCD00012466

NACRES:

NA.77

UNSPSC Code:

12352200

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.

Other Notes

Kitami, T., et al. 2012. PLoS ONE7, e33755.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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