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Merck

5.05986

SR-95531

≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem®

Synonym(s):

SR95531 (Gabazine), GABA A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531

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About This Item

Empirical Formula (Hill Notation):
C15H17N3O3 · xHBr
CAS Number:
104104-50-9
Molecular Weight:
287.31 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00055135
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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Product Name

SR95531 (Gabazine),

SMILES string

[Br-].[N+H2]=C1N(N=C(C=C1)c2ccc(cc2)OC)CCCC(=O)O

InChI

1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChI key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

potency

440 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 25 mM

storage temp.

2-8°C

Quality Level

100

Related Categories

General description

A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (Kb = 190 µM).

Biochem/physiol Actions

Primary Target
GABAA

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
5.05986.000104055977262582

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