506101
p21-Activated Kinase Inhibitor, PAK18
The p21-Activated Kinase Inhibitor, PAK18 controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
p21-Activated Kinase Inhibitor, PAK18, H₂N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO2H, PAK Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C146H254N58O37
Molecular Weight:
3413.95
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
lyophilized
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥97% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).
Biochem/physiol Actions
Cell permeable: no
Primary Target
PAK (p21-activated kinase)
PAK (p21-activated kinase)
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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