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Merck

506134

Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem

A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity.

Synonym(s):

Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem, 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ

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About This Item

Empirical Formula (Hill Notation):
C16H16N2S · xHBr
CAS Number:
60477-34-1
Molecular Weight:
268.38 (free base basis)
UNSPSC Code:
12352200

Key Documents

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Product Name

Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem, A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Product does not compete with ATP.
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
A very stable analog of Pifithrin-α (Cat. No. 506132), with biological properties similar to its parent compound, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

Other Notes

Walton, M.I., et al. 2005. Mol. Cancer Ther.4, 1369.
Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA98, 14078.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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