Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem

Name: Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem
Brand: MM

A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity.

Synonym(s):

Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem, 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆N₂S · xHBr

CAS Number:

60477-34-1

Molecular Weight:

268.38 (free base basis)

UNSPSC Code:

12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

A very stable analog of Pifithrin-α (Cat. No. 506132), with biological properties similar to its parent compound, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Other Notes

Walton, M.I., et al. 2005. Mol. Cancer Ther.4, 1369.
Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA98, 14078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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