506134
Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem
A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity.
Synonym(s):
Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem, 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ
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About This Item
Empirical Formula (Hill Notation):
C16H16N2S · xHBr
CAS Number:
Molecular Weight:
268.38 (free base basis)
UNSPSC Code:
12352200
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
A very stable analog of Pifithrin-α (Cat. No. 506132), with biological properties similar to its parent compound, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Other Notes
Walton, M.I., et al. 2005. Mol. Cancer Ther.4, 1369.
Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA98, 14078.
Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA98, 14078.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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