506156
p38 MAP Kinase Inhibitor V
The p38 MAP Kinase Inhibitor V, also referenced under CAS 271576-77-3, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
p38 MAP Kinase Inhibitor V, 4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409
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About This Item
Empirical Formula (Hill Notation):
C19H20ClN5
CAS Number:
Molecular Weight:
353.85
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light yellow
solubility
DMSO: 10 mg/mL, ethanol: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C19H20ClN5/c1-25-10-7-14(8-11-25)19-17(16-6-9-21-12-22-16)18(23-24-19)13-2-4-15(20)5-3-13/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,23,24)
InChI key
WYWOBCJMDNZHAV-UHFFFAOYSA-N
General description
A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p38 MAP Kinase
p38 MAP Kinase
Product competes with ATP.
Reversible: no
Target IC50: 20 and 40 nM, against CK1δ and p38α, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Mbalaviele, G., et al. 2006. J. Pharm. Exp. Ther.317, 1044.
Liu, Y.H., et al. 2005. J. Card. Fail.11, 74.
Yu, J.J., et al. 2003. J. Immunol.171, 6112.
Liu, Y.H., et al. 2005. J. Card. Fail.11, 74.
Yu, J.J., et al. 2003. J. Immunol.171, 6112.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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