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Merck

506157

p38 MAP Kinase Inhibitor VI, JX401

The p38 MAP Kinase Inhibitor VI, JX401, also referenced under CAS 349087-34-9, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

p38 MAP Kinase Inhibitor VI, JX401, N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C21H25NO2S
CAS Number:
349087-34-9
Molecular Weight:
355.49
UNSPSC Code:
12352200

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Product Name

p38 MAP Kinase Inhibitor VI, JX401, The p38 MAP Kinase Inhibitor VI, JX401, also referenced under CAS 349087-34-9, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InChI key

OMGLGPKQUFSRNN-UHFFFAOYSA-N

InChI

1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

ethanol: 17 mg/mL
DMSO: 26 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Disclaimer

Toxicity: Regulatory Review (Z)

General description

A cell-permeable piperidinamide compound that acts as a reversible and highly potent inhibitor of MAPK p38α (IC50 = 32 nM) with no detectable activity against p38γ even at concentrations as high as 10 µM. Shown to effectively block the differentiation of L8 myoblasts to myotubes at 10 µM in a reversible manner. Not a competitive inhibitor with respect to either ATP or substrate.

Other Notes

Friedmann, Y., et al. 2006. Mol. Pharmacol.70, 1395.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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