506158
p38 MAP Kinase Inhibitor VII, SD-169
The p38 MAP Kinase Inhibitor VII, SD-169, also referenced under CAS 1670-87-7, controls the biological activity of p38 MAP Kinase.
Synonym(s):
p38 MAP Kinase Inhibitor VII, SD-169, Indole-5-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C9H8N2O
CAS Number:
Molecular Weight:
160.17
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 1 mg/mL, DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[nH]1c2c(cc1)cc(cc2)C(=O)N
InChI
1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
InChI key
GQMYQEAXTITUAE-UHFFFAOYSA-N
General description
A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther.318, 99.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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