506163
p38 MAP Kinase Inhibitor VIII
The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
p38 MAP Kinase Inhibitor VIII, (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
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About This Item
Empirical Formula (Hill Notation):
C20H16BrClN2O
CAS Number:
Molecular Weight:
415.71
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
ethanol: 15 mg/mL, DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Brc1cc(c(cc1)Nc2cc(c(cc2)C(=O)c3c(cccc3)C)Cl)N
InChI
1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
InChI key
HDCLCHNAEZNGNV-UHFFFAOYSA-N
General description
A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC′s in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ottosen, E.R., et al. 2003. J. Med. Chem.46, 5651.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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