506181
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5
The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, TAT-Pep5, H- YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
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About This Item
Empirical Formula (Hill Notation):
C150H227N57O32S2
Molecular Weight:
3404.90
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
The p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
disulfide bond (12-26)
Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci.6, 461.
Schwarze, S.R., et al. 1999. Science285, 1569.
Schwarze, S.R., et al. 1999. Science285, 1569.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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