5.06216
Gap Junction Enhancer, PQ7
Synonym(s):
Gap Junction Enhancer, PQ7
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About This Item
Empirical Formula (Hill Notation):
C23H19F3N2O3
CAS Number:
Molecular Weight:
428.40
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
Quality Level
form
powder
potency
100 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
tan
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
General description
A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
Biochem/physiol Actions
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shishido, S.N., et al. 2013. PLos One.8, e67174.
Shishido, S.N., et al. 2012. PLos One.7,e444963.
Heiniger, B., et al. 2010. Anticancer Res.30, 3927.
Shi, A., et al. 2008. Bioor. Med. Chem. Lett.18, 3364.
Shishido, S.N., et al. 2012. PLos One.7,e444963.
Heiniger, B., et al. 2010. Anticancer Res.30, 3927.
Shi, A., et al. 2008. Bioor. Med. Chem. Lett.18, 3364.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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