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5.06272

SB 206553 Hydrochloride

Synonym(s):

SB 206553 Hydrochloride, 5-HT 2C Serotonin Receptor Antagonist, SB 206553, 5-HT 2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553

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About This Item

Empirical Formula (Hill Notation):
C17H16N4O · xHCl
CAS Number:
158942-04-2
Molecular Weight:
292.34 (free base basis)
MDL number:
MFCD00928314
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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assay

≥99% (HPLC)

Quality Segment

100

form

solid

potency

3.2 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: soluble

storage temp.

2-8°C

SMILES string

[n]1(c2c(cc3c(c2)CCN3C(=O)Nc4cnccc4)cc1)C

InChI

1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)

InChI key

QJQORSLQNXDVGE-UHFFFAOYSA-N

General description

A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).

Biochem/physiol Actions

Primary Target
5-HT2C
Secondary Target
5-HT2B

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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