Retro-inverso TAT-Beclin-1

Name: Retro-inverso TAT-Beclin-1
Brand: MM

≥95% (HPLC), Beclin Activator, powder

Synonym(s):

Beclin-1 Activator II, retro-inverso TAT-Beclin-1, (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II

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About This Item

Empirical Formula (Hill Notation):

C₁₆₄H₂₅₁N₅₇O₄₅

Molecular Weight:

3741.10

UNSPSC Code:

12352200

NACRES:

NA.77

Product Name

Beclin-1 Activator II, retro-inverso TAT-Beclin-1,

color

white

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

DMSO: 50 mg/mL
water: 50 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Cell permeable: yes

Primary Target
GAPR-1/GLIPR2

Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

Tat-beclin 1, a peptide, is derived from a segment of the autophagy protein beclin 1, which binds to human immunodeficiency virus (HIV)-1 Nef. It serves as a potent inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a recently identified negative regulator of autophagy. Tat-beclin 1 has been found to reduce the accumulation of polyglutamine expansion protein aggregates and the replication of various pathogens (including HIV-1) in vitro. Moreover, it has demonstrated the ability to decrease mortality in mice infected with chikungunya or West Nile virus.

Legal Information

Sold under license of US Patent 8,722,628.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

(D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH

Shoji-Kawata, S., et al. 2013. Nature.494, 201.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Find documentation for the products that you have recently purchased in the Document Library.

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Identification of a candidate therapeutic autophagy-inducing peptide.

Shoji-Kawata S, et al.

Nature, 494(7436), 201-201 (2013)

Global Trade Item Number

SKU	GTIN
5.06416.0001	04055977243321

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