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Merck

506600

Pamidronate, Disodium Salt

≥98% (HPLC), bone resorption inhibitor, solid

Synonym(s):

Pamidronate, Disodium Salt, 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate

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About This Item

Empirical Formula (Hill Notation):
C3H9NO7P2 · 2Na · 5H2O
CAS Number:
109552-15-0
Molecular Weight:
369.11
MDL number:
MFCD01938386
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Pamidronate, Disodium Salt, A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

SMILES string

[Na+].[Na+].[P](=O)([O-])([O-])[C@@]([P](=O)([O-])O)(O)CC[N+H3].O.O.O.O.O

InChI

1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2

InChI key

CZYWHNTUXNGDGR-UHFFFAOYSA-L

description

Merck USA index - 14, 7003

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibitor of bone resorption
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

General description

A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.

Other Notes

Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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María A Günther Sillero et al.
FEBS letters, 580(24), 5723-5727 (2006-10-03)
T4 RNA ligase catalyzes the synthesis of ATP beta,gamma-bisphosphonate analogues, using the following substrates with the relative velocity rates indicated between brackets: methylenebisphosphonate (pCH(2)p) (100), clodronate (pCCl(2)p) (52), and etidronate (pC(OH)(CH(3))p) (4). The presence of pyrophosphatase about doubled the rate

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