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Merck

5.08015

CTOP

Synonym(s):

CTOP, µ Opioid Receptor Antagonist, CTOP

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About This Item

Empirical Formula (Hill Notation):
C50H67N11O11S2
CAS Number:
103429-31-8
Molecular Weight:
1062.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00076708
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

S1SCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1(C)C)C(=O)NC(C(O)C)C(=O)N)C(O)C)CCCN)Cc4c5c([nH]c4)cccc5)Cc3ccc(cc3)O)NC(=O)C(N)Cc2ccccc2

InChI

1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)

InChI key

PZWWYAHWHHNCHO-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

potency

0.96 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: soluble

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Primary Target
mu opioid

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent antagonist highly selective for µ opioid receptor (Ki = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.

Other Notes

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)
Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.

Physical form

Supplied as trifluoracetate salt

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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