5.08048
Filastatin
Synonym(s):
Filastatin, 1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
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About This Item
Empirical Formula (Hill Notation):
C18H18ClN3O3
Molecular Weight:
359.81
UNSPSC Code:
12352101
assay
≥98% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
General description
A cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
Biochem/physiol Actions
Cell permeable: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Fazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA110, 13594.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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