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Merck

5.08052

iMDK

≥98% (HPLC), solid, midkine inhibitor, Calbiochem®

Synonym(s):

Midkine Inhibitor, iMDK, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl)-2H-chromen-2-one, MDK Expression Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C21H13FN2O2S
CAS Number:
881970-80-5
Molecular Weight:
376.40
MDL number:
MFCD07528492
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
15991416

Product Name

Midkine Inhibitor, iMDK,

InChI key

IWFKQTWYILKFGE-UHFFFAOYSA-N

SMILES string

C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CN4C=C(SC4=N3)CC5=CC=C(C=C5)F

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 5 mg/mL

storage temp.

2-8°C

Quality Level

100

Application

Midkine Inhibitor, iMDK may be used to study its anti-cancer activity on primary effusion lymphoma (PEL) in vitro.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Midkine
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

The midkine inhibitor, iMDK, demonstrates strong antiproliferative and antitumor effects both in vitro and in vivo in non-small-cell lung cancer. It also induces apoptosis of primary effusion lymphoma through G2/M cell cycle arrest.

Other Notes

Hao, H., et al. 2013. PLoS ONE8, e71093.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Midkine inhibitor (iMDK) induces apoptosis of primary effusion lymphoma via G2/M cell cycle arrest
Ueno M, et al.
Leukemia Research, 116, 106826-106826 (2022)
Novel midkine inhibitor iMDK inhibits tumor growth and angiogenesis in oral squamous cell carcinoma
Masui M, et al.
Anticancer Research, 36(6), 2775-2781 (2016)

Global Trade Item Number

SKUGTIN
5.08052.000104055977242805

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