SB 399885 Hydrochloride

Name: SB 399885 Hydrochloride
Brand: MM

Synonym(s):

SB 399885 Hydrochloride, 5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₁Cl₂N₃O₄S · xHCl

CAS Number:

402713-80-8

Molecular Weight:

446.35 (free base basis)

UNSPSC Code:

12352200

InChI key

RNKCEBCFUSXSQE-UHFFFAOYSA-N

InChI

1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;/h3-4,9-11,21-22H,5-8H2,1-2H3;1H

assay

≥99% (HPLC)

form

solid

potency

1 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mM
water: 100 mM

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

Biochem/physiol Actions

Primary Target
5-HT₆

General description

A high affinity 5-HT₆ Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT₆ receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.

Other Notes

Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664.
Li, Z. et al. 2007. Brain Res.1134, 70.

Hirst, et al. 2006. Eur. J. Pharm.553, 109.
Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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