5.08119
SB 399885 Hydrochloride
Synonym(s):
SB 399885 Hydrochloride, 5-HT6 Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885
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About This Item
Empirical Formula (Hill Notation):
C18H21Cl2N3O4S · xHCl
CAS Number:
Molecular Weight:
446.35 (free base basis)
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Level
form
solid
potency
1 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM, water: 100 mM
storage temp.
2-8°C
InChI
1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;/h3-4,9-11,21-22H,5-8H2,1-2H3;1H
InChI key
RNKCEBCFUSXSQE-UHFFFAOYSA-N
General description
A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
Biochem/physiol Actions
Primary Target
5-HT₆
5-HT₆
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664.
Li, Z. et al. 2007. Brain Res.1134, 70.
Hirst, et al. 2006. Eur. J. Pharm.553, 109.
Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.
Li, Z. et al. 2007. Brain Res.1134, 70.
Hirst, et al. 2006. Eur. J. Pharm.553, 109.
Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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