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Merck

5.08120

GR113808

Synonym(s):

GR113808, 5-HT4 Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808

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About This Item

Empirical Formula (Hill Notation):
C19H27N3O4S
CAS Number:
144625-51-4
Molecular Weight:
393.50
UNSPSC Code:
12352200
MDL number:
MFCD00912901

Key Documents

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InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

InChI key

MOZPSIXKYJUTKI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

ethanol: 10 mM
DMSO: 100 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
5-HT₄

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113 nM, rat brain membrane Kd = 0.4-1 nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81 nM).

Other Notes

Johnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther.112, 681.

Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther.283, 1000.

Gale, J. D. et al. 1994. Br. J. Pharmacol.111, 332.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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