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5.08149

SB 699551 Dihydrochloride

Name: SB 699551 Dihydrochloride
Brand: MM

Synonym(s):

SB 699551 Dihydrochloride, 5-HT _5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551, 5-HT_5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₄₅N₃O · 2HCl

CAS Number:

791789-61-2

Molecular Weight:

584.66

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 10 mM, DMSO: 25 mM

storage temp.

2-8°C

InChI

1S/C34H45N3O/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3

InChI key

SEQAMPXQRKYYQF-UHFFFAOYSA-N

Description

General description

A selective, brain penetrant, 5-HT_5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT_5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT_1A/B/D, 5-HT_2A/C and 5-5-HT₇).

Biochem/physiol Actions

Primary Target
5-HT_5A

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ferenc, K. et al. 2012. Behav. Pharmacol.23, 397.
Thomas, D. R. et al. 2006. Neuropharmacol.51, 566.
Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett.15, 4014.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c