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5.08150

LY 344864 Hydrochloride

Synonym(s):

LY 344864 Hydrochloride, 5-HT 1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864, 5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864

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About This Item

Empirical Formula (Hill Notation):
C21H22FN3O · xHCl
CAS Number:
186544-26-3
Molecular Weight:
351.42 (free base basis)
UNSPSC Code:
12352200
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assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 10 mM, DMSO: 100 mM

storage temp.

2-8°C

InChI

1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1

InChI key

OKUHLSYESBLBCP-PKLMIRHRSA-N

General description

A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)

Biochem/physiol Actions

Primary Target
5-HT1F

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Amrutkar, D. V. et al. 2012. Pain.153, 830.

Phebus, L. A. et al. 1997. Life Sci.61, 2117.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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